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<table width="100%" summary="page for Indometh"><tr><td>Indometh</td><td style="text-align: right;">R Documentation</td></tr></table>

<h2>Pharmacokinetics of Indomethacin</h2>

<h3>Description</h3>

<p>The <code>Indometh</code> data frame has 66 rows and 3 columns of data on
the pharmacokinetics of indometacin (or, older spelling,
&lsquo;indomethacin&rsquo;).
</p>


<h3>Usage</h3>

<pre>Indometh</pre>


<h3>Format</h3>

<p>An object of class
<code>c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame")</code>
containing the following columns:
</p>

<dl>
<dt>Subject</dt><dd>
<p>an ordered factor with containing the subject codes.  The
ordering is according to increasing maximum response.
</p>
</dd>
<dt>time</dt><dd>
<p>a numeric vector of times at which blood samples were drawn (hr).
</p>
</dd>
<dt>conc</dt><dd>
<p>a numeric vector of plasma concentrations of indometacin (mcg/ml).
</p>
</dd>
</dl>



<h3>Details</h3>

<p>Each of the six subjects were given an intravenous injection of
indometacin.
</p>
<p>This dataset was originally part of package <code>nlme</code>, and that has
methods (including for <code>[</code>, <code>as.data.frame</code>, <code>plot</code> and
<code>print</code>) for its grouped-data classes.
</p>


<h3>Source</h3>

<p>Kwan, Breault, Umbenhauer, McMahon and Duggan (1976)
Kinetics of Indomethacin absorption, elimination, and
enterohepatic circulation in man.
<em>Journal of Pharmacokinetics and Biopharmaceutics</em> <b>4</b>,
255&ndash;280.
</p>
<p>Davidian, M. and Giltinan, D. M. (1995)
<em>Nonlinear Models for Repeated Measurement Data</em>,
Chapman &amp; Hall (section 5.2.4, p. 129)
</p>
<p>Pinheiro, J. C. and Bates, D. M. (2000) <em>Mixed-effects Models in
S and S-PLUS</em>, Springer.
</p>


<h3>See Also</h3>

<p><code>SSbiexp</code> for models fitted to this dataset.
</p>


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